As yet, our endeavor has been confined to highlighting and expounding the major advances in the recognition of multiple sclerosis as a distinct kind of pathology. The key features of the condition's prototypical or standard specimens, i.e. the sole identifying features of a spinal and cerebral damage as an instance of multiple sclerosis -- multiple sclerosis being understood in the term's specific and original sense -- have thus become evident. The significance of the tissue changes inside the distinctive spinal and cerebral lesion domains will be focused on next.