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  1. Challenges
  2. (I) Multiple sclerosis: Genuine naked-eye identification
    1. (I-1) Pioneering spinal cord findings
    2. (I-2) Detection of distinctive brain lesions
    3. (I-3) Macropathology: Unexploited key evidence
  3. (II) Histological perspectives
    1. (II-1) Tissue changes in specific lesions
    2. (II-2) Histological lesion categorizations
    3. (II-3) “Selective demyelination”: The facts
  4. (III) The neurologist’s standpoint
    1. (III-1) Classical clinical observations
      1. Cruveilhier, 1841: First clinical account of multiple sclerosis
      2. Clinical manifestations of Charcot’s specific lateral cord lesion
      3. Neurological data on Frommann’s observation
      4. Charcot’s prime clinical example of cerebrospinal sclerosis
      5. Lauenstein’s myelitis
      6. Clinical history of Dawson’s standard of comparison
      7. Reflections on classical clinical observations
    2. (III-2) CDMS: Chronically delusive misidentification syndrome
  5. (IV) The specter of the multiple sclerosis agent
    1. (IV-1) Lawless or specific pattern(s) of spread?
    2. (IV-2) From randomly spread foci to multiple sclerosis-agent
    3. (IV-3) Looking back in frustration
  6. (V) Lesion explanation in physical terms
    1. (V-1) The dynamics of lesion formation
    2. (V-2) Cause of the injurious impulses
    3. (V-3) The key to decoding multiple sclerosis: Specific data
  7. References
  8. Overview of Plates

    © Dr. F. Alfons Schelling, M.D.