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  1. Challenges
  2. (I) Multiple sclerosis: Genuine naked-eye identification
    1. (I-1) Pioneering spinal cord findings
    2. (I-2) Detection of distinctive brain lesions
    3. (I-3) Macropathology: Unexploited key evidence
  3. (II) Histological perspectives
    1. (II-1) Tissue changes in specific lesions
    2. (II-2) Histological lesion categorizations
    3. (II-3) “Selective demyelination”: The facts
  4. (III) The neurologist’s standpoint
    1. (III-1) Classical clinical observations
    2. (III-2) CDMS: Chronically delusive misidentification syndrome
      1. (III-2-a) The first clinical cases
        1. Frerichs' (cryptic) cerebral sclerosis
        2. First clinical diagnosis of cerebrospinal sclerosis
        3. Ordenstein’s prototypal clinical reports
        4. Charcot: Multiple sclerosis – a kind of lesion, yet clinically defined
      2. (III-2-b) Mutations of the multiple sclerosis syndrome
      3. (III-2-c) Framing of new clinical criteria
  5. (IV) The specter of the multiple sclerosis agent
    1. (IV-1) Lawless or specific pattern(s) of spread?
    2. (IV-2) From randomly spread foci to multiple sclerosis-agent
    3. (IV-3) Looking back in frustration
  6. (V) Lesion explanation in physical terms
    1. (V-1) The dynamics of lesion formation
    2. (V-2) Cause of the injurious impulses
    3. (V-3) The key to decoding multiple sclerosis: Specific data
  7. References
  8. Overview of Plates

    © Dr. F. Alfons Schelling, M.D.